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Bernardo R. T. R. et al. · Skin Research and Technology 30(4):e13681 · 2024
Effect of poly-L-lactic acid and polydioxanone biostimulators on type I and III collagen biosynthesis
Key finding
PDO produced the most active new type III collagen formation, with better-organised collagen bundles than PLLA.
Summary
A histology comparison of PDO and PLLA (poly-L-lactic acid) 30 days after injection. Collagen was assessed with picrosirius red staining under polarised light.
Both biostimulators increased type III collagen, but PDO produced the most, spread evenly in compact, well-ordered bundles. PLLA stayed in encapsulated clusters, while PDO dispersed diffusely through the tissue.
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