Quantitative Assessment of Polydioxanone Microsphere Fillers for Nasolabial Fold Correction: A Comparative Study

A prospective split-face study: each participant received PDO microspheres (Ultracol) in one nasolabial fold and an established product in the other, either hyaluronic acid, PDLLA or polynucleotides. 1 mL per fold, two sessions 4 weeks apart, measured with ANTERA 3D imaging.

At week 8 the PDO side showed a 22.68% improvement in sunken volume (vs 7.69% for hyaluronic acid) and 12.07% smoother texture, 2.22× the PDLLA group. Improvement built up steadily across the follow-up.